|Application ||WB, E|
|Calculated MW||42557 Da|
|Antigen Region||302-331 aa|
|Other Names||Cyclin-I, CCNI|
|Target/Specificity||This CCNI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 302-331 amino acids from the C-terminal region of human CCNI.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CCNI Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Highest levels in adult heart, brain and skeletal muscle. Lower levels in adult placenta, lung, kidney and pancreas. Also high levels in fetal brain and lower levels in fetal lung, liver and kidney. Also abundant in testis and thyroid|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. The function of this cyclin has not yet been determined.
Sun, Z.L., et al. Biochim. Biophys. Acta 1774(6):764-771(2007)
Zhu, X., et al. Biochem. Biophys. Res. Commun. 249(1):56-60(1998)
Nakamura, T., et al. Exp. Cell Res. 221(2):534-542(1995)
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