|Application ||WB, IHC-P, E|
|Calculated MW||90208 Da|
|Antigen Region||716-745 aa|
|Other Names||Sushi domain-containing protein 2, SUSD2|
|Target/Specificity||This SUSD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 716-745 amino acids from the C-terminal region of human SUSD2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SUSD2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=SUSD2 and LGALS1 co-localized in very specific, punctate regions along the cell membrane of breast cancer cells.|
|Tissue Location||Highly expressed in breast cancer, but shows a restricted expression pattern in normal tissues such as adipose, adrenal gland, kidney, lung, mammary gland, placenta, thyroid, trachea, and uterus (PubMed:23131994). Also expressed in colon; down-regulated in colon cancer tissues (PubMed:25351403)|
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Provided below are standard protocols that you may find useful for product applications.
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Liu, T., et al. J. Proteome Res. 4(6):2070-2080(2005)
Dunham, I., et al. Nature 402(6761):489-495(1999)
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