SUSD2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q9UGT4 |
Other Accession | NP_062547.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 90208 Da |
Antigen Region | 716-745 aa |
Gene ID | 56241 |
---|---|
Other Names | Sushi domain-containing protein 2, SUSD2 |
Target/Specificity | This SUSD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 716-745 amino acids from the C-terminal region of human SUSD2. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SUSD2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SUSD2 |
---|---|
Function | May be a cytokine receptor for GPR15LG. May be a tumor suppressor; together with GPR15LG has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994). |
Cellular Location | Cell membrane; Single-pass type I membrane protein. Note=SUSD2 and LGALS1 co-localized in very specific, punctate regions along the cell membrane of breast cancer cells |
Tissue Location | Highly expressed in breast cancer, but shows a restricted expression pattern in normal tissues such as adipose, adrenal gland, kidney, lung, mammary gland, placenta, thyroid, trachea, and uterus (PubMed:23131994). Also expressed in colon; down-regulated in colon cancer tissues (PubMed:25351403) |
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Provided below are standard protocols that you may find useful for product applications.
References
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Liu, T., et al. J. Proteome Res. 4(6):2070-2080(2005)
Dunham, I., et al. Nature 402(6761):489-495(1999)
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