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KAT2A Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP13089b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP13089b-ev20 | Ev20 size 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
KAT2A Antibody (C-term) - Product info | |
| Application | WB
|
| Primary Accession | Q92830 |
| Other Accession | Q9JHD2, NP_066564.2 |
| Reactivity | Human |
| Predicted | Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 93926 Da |
KAT2A Antibody (C-term) - Additional info | |
| Gene ID 2648 | |
| Other Names KAT2A; GCN5; GCN5L2; HGCN5; Histone acetyltransferase KAT2A; General control of amino acid synthesis protein 5-like 2; Histone acetyltransferase GCN5; Lysine acetyltransferase 2A; STAF97 | |
| Target/Specificity This KAT2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 610-638 amino acids from the C-terminal region of human KAT2A. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions KAT2A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
KAT2A Antibody (C-term) - Protein Information | |
| Name KAT2A | |
| Synonyms GCN5, GCN5L2, HGCN5 | |
| Function Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 | |
| Cellular Location Nucleus. | |
| Tissue Location Expressed in all tissues tested, with most abundant expression in ovary | |
KAT2A Antibody (C-term) - Related products
AP1078b: GCN5 (GCN5L2) Antibody (C-term)
AP1078d: GCN5 Antibody (N-term)
AP12198b: hGCN5 Antibody (C-term)
AP13089b: KAT2A Antibody (C-term)
RI12830: KAT2A predesign siRNA
BP1078a: GCN5L2 Antibody (N-term) Blocking Peptide
BP1078b: GCN5L2 Antibody (C-term) Blocking Peptide
KAT2A Antibody (C-term) - Application data
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KAT2A Antibody (C-term) (Cat. #AP13089b) western blot analysis in UM cell line lysates (35ug/lane).This demonstrates the KAT2A antibody detected the KAT2A protein (arrow).
KAT2A Antibody (C-term) - Research Areas
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BACKGROUND
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).
REFERENCES
Terreni, M., et al. Retrovirology 7, 18 (2010) : Atanassov, B.S., et al. Mol. Cell 35(3):352-364(2009) Kelly, T.J., et al. J. Biol. Chem. 284(30):19945-19952(2009) Mao, X., et al. Genes Dev. 23(7):849-861(2009) Paolinelli, R., et al. Nat. Struct. Mol. Biol. 16(4):412-420(2009)
