|Application ||WB, IHC-P, E|
|Calculated MW||20508 Da|
|Antigen Region||115-150 aa|
|Other Names||Bcl-2-modifying factor, BMF|
|Target/Specificity||This Bmf BH3 Domain antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-150 amino acids from human Bmf BH3 Domain.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Bmf BH3 Domain Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in apoptosis. Isoform 1 seems to be the main initiator.|
|Tissue Location||Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells.|
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Provided below are standard protocols that you may find useful for product applications.
Bmf belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis.
Puthalakath, H., et al., Science 293(5536):1829-1832 (2001).
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