|Application ||WB, IHC-P, E|
|Calculated MW||79152 Da|
|Antigen Region||494-522 aa|
|Other Names||Protein phosphatase 1 regulatory subunit 15B, PPP1R15B|
|Target/Specificity||This PR15B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 494-522 amino acids from the C-terminal region of human PR15B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PR15B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1.|
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Provided below are standard protocols that you may find useful for product applications.
PPP1R15B promotes dephosphorylation of the transcription initiation factor EIF2-alpha (EIF2S1; MIM 603907) through recruitment of protein phosphatase-1 (PP1) catalytic subunits (see MIM 176875) (Harding et al., 2009 [PubMed 19181853]).[supplied by OMIM].
Harding, H.P., et al. Proc. Natl. Acad. Sci. U.S.A. 106(6):1832-1837(2009)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
Ceulemans, H., et al. Bioessays 24(4):371-381(2002)
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