|Application ||WB, IHC-P, E|
|Other Accession||Q99MZ4, Q99JP7, NP_821158.2|
|Calculated MW||70467 Da|
|Antigen Region||24-53 aa|
|Other Names||Gamma-glutamyltransferase 7, GGT 7, Gamma-glutamyltransferase-like 3, Gamma-glutamyltransferase-like 5, Gamma-glutamyltranspeptidase 7, Glutathione hydrolase 7, Gamma-glutamyltransferase 7 heavy chain, Gamma-glutamyltransferase 7 light chain, GGT7, GGTL3, GGTL5|
|Target/Specificity||This GGT7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-53 amino acids from the N-terminal region of human GGT7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GGT7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves glutathione conjugates.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Heisterkamp, N., et al. Hum. Genet. 123(4):321-332(2008)
He, X., et al. Biochem. Biophys. Res. Commun. 297(3):528-536(2002)
Figlewicz, D.A., et al. Genomics 17(2):299-305(1993)
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