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CAPN8 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | A6NHC0 |
| Other Accession | NP_001137434.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 79144 Da |
| Antigen Region | 290-318 aa |
| Gene ID | 388743 |
|---|---|
| Other Names | Calpain-8, New calpain 2, nCL-2, Stomach-specific M-type calpain, CAPN8, NCL2 |
| Target/Specificity | This CAPN8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290-318 amino acids from the Central region of human CAPN8. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CAPN8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CAPN8 |
|---|---|
| Synonyms | NCL2 |
| Function | Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity). |
| Cellular Location | Cytoplasm. Golgi apparatus |
| Tissue Location | Stomach. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).
References
Hata, S., et al. J. Biol. Chem. 282(38):27847-27856(2007)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
Hata, S., et al. J. Mol. Evol. 53(3):191-203(2001)
Huang, Y., et al. Trends Mol Med 7(8):355-362(2001)
Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001)
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