|Application ||WB, IHC-P, E|
|Calculated MW||79144 Da|
|Antigen Region||290-318 aa|
|Other Names||Calpain-8, New calpain 2, nCL-2, Stomach-specific M-type calpain, CAPN8, NCL2|
|Target/Specificity||This CAPN8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290-318 amino acids from the Central region of human CAPN8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CAPN8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta- subunit of coatomer complex (By similarity).|
|Cellular Location||Cytoplasm. Golgi apparatus|
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Provided below are standard protocols that you may find useful for product applications.
Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).
Hata, S., et al. J. Biol. Chem. 282(38):27847-27856(2007)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
Hata, S., et al. J. Mol. Evol. 53(3):191-203(2001)
Huang, Y., et al. Trends Mol Med 7(8):355-362(2001)
Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001)
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