NEURL3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | Q96EH8 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 28789 Da |
Antigen Region | 234-262 aa |
Gene ID | 93082 |
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Other Names | E3 ubiquitin-protein ligase NEURL3, 632-, Lung-inducible neuralized-related C3CH4 RING domain protein, Neuralized-like protein 3, NEURL3, LINCR |
Target/Specificity | This NEURL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 234-262 amino acids from the C-terminal region of human NEURL3. |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | NEURL3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NEURL3 |
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Synonyms | LINCR |
Function | E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity (PubMed:30111563). Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7 (PubMed:35792897). Inhibits also hepatitis C virus assembly by directly binding to viral E1 envelope glycoprotein to disrupt its interaction with E2 (PubMed:30111563). |
Cellular Location | Cytoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
E3 ubiquitin-protein ligase. It seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not involved in tagging substrates for proteosomal degradation (By similarity).
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