|Application ||WB, IHC-P, E|
|Other Accession||Q8JZQ2, Q2KJI7, NP_006787.2|
|Calculated MW||88584 Da|
|Antigen Region||52-80 aa|
|Other Names||AFG3-like protein 2, 3424-, Paraplegin-like protein, AFG3L2|
|Target/Specificity||This AFG3L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-80 amino acids from the N-terminal region of human AFG3L2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AFG3L2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||ATP-dependent protease which is essential for axonal development.|
|Cellular Location||Mitochondrion membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitous. Highly expressed in the cerebellar Purkinje cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders.
Edener, U., et al. Eur. J. Hum. Genet. 18(8):965-968(2010)
Di Bella, D., et al. Nat. Genet. 42(4):313-321(2010)
Augustin, S., et al. Mol. Cell 35(5):574-585(2009)
Mariotti, C., et al. Cerebellum 7(2):184-188(2008)
Cagnoli, C., et al. Brain 129 (PT 1), 235-242 (2006) :
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