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PDE6A Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PDE6A Antibody (Center) AP13220C
    PDE6A Antibody (Center) (Cat. #AP13220c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PDE6A antibody detected the PDE6A protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P16499
Other Accession P27664, P11541, NP_000431.2
Reactivity Human
Predicted Bovine, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 99547 Da
Antigen Region 308-336 aa
Additional Information
Gene ID 5145
Other Names Rod cGMP-specific 3', 5'-cyclic phosphodiesterase subunit alpha, GMP-PDE alpha, PDE V-B1, PDE6A, PDEA
Target/Specificity This PDE6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDE6A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPDE6A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDE6A
Synonyms PDEA
Function This protein participates in processes of transmission and amplification of the visual signal.
Cellular Location Cell membrane; Lipid-anchor; Cytoplasmic side
Research Areas
Citations (0)

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This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.


Clark, G.R., et al. Ophthalmology 117(11):2169-2177(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Perlis, R.H., et al. Biol. Psychiatry 67(11):1110-1113(2010)
Bazhin, A.V., et al. Cell. Mol. Life Sci. 67(5):817-828(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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$ 295.00
$ 99.00
Cat# AP13220C
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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