|Application ||WB, E|
|Other Accession||P27664, P11541, NP_000431.2|
|Calculated MW||99547 Da|
|Antigen Region||308-336 aa|
|Other Names||Rod cGMP-specific 3', 5'-cyclic phosphodiesterase subunit alpha, GMP-PDE alpha, PDE V-B1, PDE6A, PDEA|
|Target/Specificity||This PDE6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDE6A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PDE6A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This protein participates in processes of transmission and amplification of the visual signal.|
|Cellular Location||Cell membrane; Lipid-anchor; Cytoplasmic side|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
Clark, G.R., et al. Ophthalmology 117(11):2169-2177(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Perlis, R.H., et al. Biol. Psychiatry 67(11):1110-1113(2010)
Bazhin, A.V., et al. Cell. Mol. Life Sci. 67(5):817-828(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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