|Application ||WB, E|
|Other Accession||NP_665705.1, NP_071422.1|
|Calculated MW||31670 Da|
|Antigen Region||156-184 aa|
|Other Names||GDNF family receptor alpha-4, GDNF receptor alpha-4, GDNFR-alpha-4, GFR-alpha-4, Persephin receptor, GFRA4|
|Target/Specificity||This GFRA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-184 amino acids from the Central region of human GFRA4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GFRA4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.|
|Cellular Location||Isoform GFRalpha4a: Cell membrane; Lipid- anchor, GPI-anchor Isoform GFRalpha4c: Secreted.|
|Tissue Location||Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Yang, J., et al. FEBS Lett. 569 (1-3), 267-271 (2004) :
Borrego, S., et al. J. Med. Genet. 40 (3), E18 (2003) :
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Zhou, B., et al. Pediatr. Neurol. 25(2):156-161(2001)
Lindahl, M., et al. J. Biol. Chem. 276(12):9344-9351(2001)
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