|Application ||WB, IHC-P, E|
|Other Accession||B1H278, A0JN74, NP_660215.1|
|Calculated MW||52774 Da|
|Antigen Region||300-329 aa|
|Other Names||E3 ubiquitin-protein ligase TRIM11, 632-, Protein BIA1, RING finger protein 92, Tripartite motif-containing protein 11, TRIM11, RNF92|
|Target/Specificity||This TRIM11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-329 amino acids from the C-terminal region of human TRIM11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRIM11 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.|
|Cellular Location||Cytoplasm. Nucleus.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq].
Aurino, S., et al. Acta Myol 27, 90-97 (2008) :
Hong, S.J., et al. Biochem. Biophys. Res. Commun. 368(3):650-655(2008)
Uchil, P.D., et al. PLoS Pathog. 4 (2), E16 (2008) :
Ishikawa, H., et al. FEBS Lett. 580(20):4784-4792(2006)
Cooper, S.T., et al. BMC Genet. 6, 43 (2005) :
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