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TRIM11 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TRIM11 Antibody (C-term) AP13284B
    TRIM11 Antibody (C-term) (Cat. #AP13284b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TRIM11 antibody detected the TRIM11 protein (arrow).
  • IHC-P - TRIM11 Antibody (C-term) AP13284B
    TRIM11 Antibody (C-term) (Cat. #AP13284b)immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TRIM11 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96F44
Other Accession B1H278, A0JN74, NP_660215.1
Reactivity Human
Predicted Bovine, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 52774 Da
Antigen Region 300-329 aa
Additional Information
Gene ID 81559
Other Names E3 ubiquitin-protein ligase TRIM11, 632-, Protein BIA1, RING finger protein 92, Tripartite motif-containing protein 11, TRIM11, RNF92
Target/Specificity This TRIM11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-329 amino acids from the C-terminal region of human TRIM11.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTRIM11 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM11
Synonyms RNF92
Function E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.
Cellular Location Cytoplasm. Nucleus.
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq].


Aurino, S., et al. Acta Myol 27, 90-97 (2008) :
Hong, S.J., et al. Biochem. Biophys. Res. Commun. 368(3):650-655(2008)
Uchil, P.D., et al. PLoS Pathog. 4 (2), E16 (2008) :
Ishikawa, H., et al. FEBS Lett. 580(20):4784-4792(2006)
Cooper, S.T., et al. BMC Genet. 6, 43 (2005) :

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$ 295.00
$ 99.00
Cat# AP13284B
(40 western blots)
Availability: In Stock
Bulk Size
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