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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TRIM13 Antibody (N-term)   

TRIM13 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TRIM13 Antibody (N-term) AP13285a
    TRIM13 Antibody (N-term) (Cat. #AP13285a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TRIM13 antibody detected the TRIM13 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O60858
Other Accession Q5M7V1, Q9CYB0, NP_005789.2, NP_434698.1, NP_001007279.1, NP_998755.1
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 46988 Da
Antigen Region 61-90 aa
Additional Information
Gene ID 10206
Other Names E3 ubiquitin-protein ligase TRIM13, 632-, B-cell chronic lymphocytic leukemia tumor suppressor Leu5, Leukemia-associated protein 5, Putative tumor suppressor RFP2, RING finger protein 77, Ret finger protein 2, Tripartite motif-containing protein 13, TRIM13, LEU5, RFP2, RNF77
Target/Specificity This TRIM13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-90 amino acids from the N-terminal region of human TRIM13.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTRIM13 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM13
Synonyms LEU5, RFP2, RNF77
Function E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Concentrates and colocalizes with p62/SQSTM1 and ZFYVE1 at the perinuclear endoplasmic reticulum
Research Areas
Citations (0)

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This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene.


Lerner, M., et al. Mol. Biol. Cell 18(5):1670-1682(2007)
Skoblov, M., et al. Biochem. Biophys. Res. Commun. 342(3):859-866(2006)
Corcoran, M.M., et al. Genes Chromosomes Cancer 40(4):285-297(2004)
Dunham, A., et al. Nature 428(6982):522-528(2004)
van Everdink, W.J., et al. Cancer Genet. Cytogenet. 146(1):48-57(2003)

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$ 295.00
$ 99.00
Cat# AP13285a
(40 western blots)
Availability: In Stock
Bulk Size
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