|Application ||WB, IHC-P, E|
|Calculated MW||44455 Da|
|Antigen Region||364-395 aa|
|Other Names||Threonine aspartase 1, Taspase-1, 3425-, Threonine aspartase subunit alpha, Threonine aspartase subunit beta, TASP1, C20orf13|
|Target/Specificity||This TASP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-395 amino acids from the C-terminal region of human TASP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TASP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protease involved in KMT2A/MLL1 processing and, consequently, in the correct expression of the early HOXA gene cluster.|
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Provided below are standard protocols that you may find useful for product applications.
TASP1 is an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor.
Hsieh, J.J., et al., Cell 115(3):293-303 (2003).
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