SGEF Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q96DR7 |
Other Accession | NP_056410.3 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 97346 Da |
Antigen Region | 378-406 aa |
Gene ID | 26084 |
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Other Names | Rho guanine nucleotide exchange factor 26, SH3 domain-containing guanine exchange factor, ARHGEF26, SGEF |
Target/Specificity | This SGEF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 378-406 amino acids from the Central region of human SGEF. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SGEF Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ARHGEF26 |
---|---|
Synonyms | SGEF |
Function | Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. |
Cellular Location | Cell projection, ruffle |
Tissue Location | Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
SGEF activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.
References
Yamada, S., et al. Oncogene 23(35):5901-5911(2004)
Ellerbroek, S.M., et al. Mol. Biol. Cell 15(7):3309-3319(2004)
Qi, H., et al. Endocrinology 144(5):1742-1752(2003)
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