|Application ||WB, IHC-P, E|
|Other Accession||Q60900, NP_115657.2, NP_001411.2|
|Calculated MW||39547 Da|
|Antigen Region||71-99 aa|
|Other Names||ELAV-like protein 3, Hu-antigen C, HuC, Paraneoplastic cerebellar degeneration-associated antigen, Paraneoplastic limbic encephalitis antigen 21, ELAVL3, HUC, PLE21|
|Target/Specificity||This ELAVL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-99 amino acids from the N-terminal region of human ELAVL3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ELAVL3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance.|
|Tissue Location||Brain specific.|
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Provided below are standard protocols that you may find useful for product applications.
A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Behrends, U., et al. Int. J. Cancer 100(6):669-677(2002)
Park, S., et al. Mol. Cell. Biol. 20(13):4765-4772(2000)
King, P.H. Nucleic Acids Res. 28 (7), E20 (2000) :
Sakai, K., et al. Biochem. Biophys. Res. Commun. 256(2):263-268(1999)
Van Tine, B.A., et al. Genomics 53(3):296-299(1998)
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