|Application ||WB, E|
|Other Accession||NP_001139188.1, NP_001139189.2, NP_775947.2|
|Calculated MW||57875 Da|
|Antigen Region||1-30 aa|
|Other Names||Patatin-like phospholipase domain-containing protein 1, 311-, PNPLA1|
|Target/Specificity||This PNPLA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PNPLA1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PNPLA1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Lipid hydrolase. Important in the formation of the epidermal lipid barrier. Plays a role in glycerophospholipid metabolism.|
|Cellular Location||Cytoplasm. Note=Clearly distributed in the cytoplasm of keratinocytes|
|Tissue Location||Expressed in the digestive system. Expressed in the epidermis of skin keratinocytes. Strongly expressed in the granular layer. Expressed in the upper epidermis and eccrine sweat glands of the dermis and in the region of keratin filament bundles, which is more pronounced in upper epidermal layers and in the lower cornified layers.|
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Provided below are standard protocols that you may find useful for product applications.
Human patatin-like phospholipases, such as PNPLA1, have been implicated in regulation of adipocyte differentiation and have been induced by metabolic stimuli (Wilson et al., 2006 [PubMed 16799181]).
Kienesberger, P.C., et al. J. Lipid Res. 50 SUPPL, S63-S68 (2009) :
Johansson, L.E., et al. PLoS ONE 4 (4), E5327 (2009) :
De Chaudhuri, S., et al. Environ. Health Perspect. 116(4):501-505(2008)
Wilson, P.A., et al. J. Lipid Res. 47(9):1940-1949(2006)
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