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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TFCP2L1 Antibody (Center)   

TFCP2L1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TFCP2L1 Antibody (Center) AP13367C
    TFCP2L1 Antibody (Center) (Cat. #AP13367c) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the TFCP2L1 antibody detected the TFCP2L1 protein (arrow).
  • WB - TFCP2L1 Antibody (Center) AP13367C
    TFCP2L1 Antibody (Center) (Cat. #AP13367c) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the TFCP2L1 antibody detected the TFCP2L1 protein (arrow).
  • IHC-P - TFCP2L1 Antibody (Center) AP13367C
    TFCP2L1 Antibody (Center) (Cat. #AP13367c)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TFCP2L1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - TFCP2L1 Antibody (Center) AP13367C
    TFCP2L1 Antibody (Center) (Cat. #AP13367c) flow cytometric analysis of WiDr cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NZI6
Other Accession Q3UNW5, NP_055368.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 54627 Da
Antigen Region 222-251 aa
Additional Information
Gene ID 29842
Other Names Transcription factor CP2-like protein 1, CP2-related transcriptional repressor 1, CRTR-1, Transcription factor LBP-9, TFCP2L1, CRTR1, LBP9
Target/Specificity This TFCP2L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-251 amino acids from the Central region of human TFCP2L1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTFCP2L1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TFCP2L1
Synonyms CRTR1, LBP9
Function Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:25215486, PubMed:26906118). With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity). Required for normal duct development in the salivary gland and kidney (By similarity). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (By similarity). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity). Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity). JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity). Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (By similarity). Modulates the placental expression of CYP11A1 (PubMed:10644752).
Cellular Location Nucleus.
Tissue Location Highly expressed in placental JEG-3 cells and very low levels of expression in non-steroidogenic cells. No expression was seen in adrenal NCI-H295A cells or in adrenal tissue.
Research Areas
Citations (0)

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TFCP2L1is a transcriptional suppressor. It may suppress UBP1-mediated transcriptional activation. Modulates the placental expression of CYP11A1.


To, S., et al. PLoS ONE 5 (7), E11702 (2010) :
Henderson, Y.C., et al. DNA Cell Biol. 27(2):71-79(2008)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
Huang, N., et al. Mol. Endocrinol. 19(2):409-420(2005)
Rodda, S., et al. J. Biol. Chem. 276(5):3324-3332(2001)

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$ 295.00
$ 99.00
Cat# AP13367C
(40 western blots)
Availability: In Stock
Bulk Size
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