|Application ||WB, IHC-P, E|
|Other Accession||P14126, P21531, Q29293, P27659, Q4R5Q0, P39872, NP_000958.1|
|Predicted||Bovine, Monkey, Mouse, Pig, Rat, Yeast|
|Calculated MW||46109 Da|
|Antigen Region||224-251 aa|
|Other Names||60S ribosomal protein L3, HIV-1 TAR RNA-binding protein B, TARBP-B, RPL3|
|Target/Specificity||This RPL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-251 amino acids from the Central region of human RPL3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RPL3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The L3 protein is a component of the large subunit of cytoplasmic ribosomes.|
|Cellular Location||Nucleus, nucleolus. Cytoplasm|
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Provided below are standard protocols that you may find useful for product applications.
Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq].
Russo, A., et al. Biochim. Biophys. Acta 1799 (5-6), 419-428 (2010) :
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Tu, L.C., et al. Mol. Cell Proteomics 6(4):575-588(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Bergqvist, M., et al. Dis. Esophagus 19(1):20-23(2006)
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