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PHF17 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PHF17 Antibody (N-term) AP13432a
    Western blot analysis of lysate from U-251 MG cell line, using PHF17 Antibody (N-term)(Cat. #AP13432a). AP13432a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.
  • IHC-P - PHF17 Antibody (N-term) AP13432a
    PHF17 Antibody (N-term) (Cat. #AP13432a)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PHF17 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q6IE81
Other Accession NP_079176.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 95533 Da
Antigen Region 22-51 aa
Additional Information
Gene ID 79960
Other Names Protein Jade-1, Jade family PHD finger protein 1, PHD finger protein 17, JADE1, KIAA1807, PHF17
Target/Specificity This PHF17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-51 amino acids from the N-terminal region of human PHF17.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPHF17 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name JADE1
Synonyms KIAA1807, PHF17
Function Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor.
Cellular Location Cytoplasm. Nucleus.
Tissue Location Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells.
Citations (0)

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Background

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor.

References

Foy, R.L., et al. J. Biol. Chem. 283(43):28817-28826(2008)
Chitalia, V.C., et al. Nat. Cell Biol. 10(10):1208-1216(2008)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Lim, J., et al. Cell 125(4):801-814(2006)
Doyon, Y., et al. Mol. Cell 21(1):51-64(2006)

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$ 295.00
$ 99.00
Cat# AP13432a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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