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>   home   >   Products   >   Primary Antibodies   >   Cardiovascular   >   JPH2 Antibody (C-term)   

JPH2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - JPH2 Antibody (C-term) AP13445b
    JPH2 Antibody (C-term) (Cat. #AP13445b) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the JPH2 antibody detected the JPH2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BR39
Other Accession NP_065166.2, NP_787109.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 74222 Da
Antigen Region 614-643 aa
Additional Information
Gene ID 57158
Other Names Junctophilin-2, JP-2, Junctophilin type 2, JPH2, JP2
Target/Specificity This JPH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 614-643 amino acids from the C-terminal region of human JPH2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsJPH2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name JPH2
Synonyms JP2
Function Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH2 is necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions.
Cellular Location Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands (By similarity).
Tissue Location Specifically expressed in skeletal muscle and heart.
Research Areas
Citations (0)

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Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Woo, J.S., et al. Biochem. J. 427(1):125-134(2010)
Yamazaki, D., et al. Pharmacol. Ther. 121(3):265-272(2009)
Landstrom, A.P., et al. J. Mol. Cell. Cardiol. 42(6):1026-1035(2007)
Matsushita, Y., et al. J. Hum. Genet. 52(6):543-548(2007)

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$ 295.00
$ 99.00
Cat# AP13445b
(40 western blots)
Availability: In Stock
Bulk Size
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