|Application ||WB, E|
|Calculated MW||39248 Da|
|Antigen Region||20-49 aa|
|Other Names||Tubulin-specific chaperone C, Tubulin-folding cofactor C, CFC, TBCC|
|Target/Specificity||This TBCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human TBCC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TBCC Antibody (N-term ) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tubulin-folding protein; involved in the final step of the tubulin folding pathway.|
|Cellular Location||Cytoplasm. Note=Detected predominantly in the photoreceptor connecting cilium|
|Tissue Location||Expressed in the retina. Expressed in the rod and cone photoreceptors, extending from the inner segments (IS), through the outer nuclear layer (ONL) and into the synapses in the outer plexiform layer (OPL). Strongly expressed to the photoreceptor connecting cilium at the tips of the IS (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.
Hage-Sleiman, R., et al. BMC Cancer 10, 135 (2010) :
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Bartolini, F., et al. J. Biol. Chem. 277(17):14629-14634(2002)
Tian, G., et al. Cell 86(2):287-296(1996)
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