|Application ||WB, E|
|Other Accession||Q80V91, NP_848597.1|
|Calculated MW||37988 Da|
|Antigen Region||20-48 aa|
|Other Names||Probable E3 ubiquitin-protein ligase DTX3, 632-, Protein deltex-3, Deltex3, RING finger protein 154, DTX3, RNF154|
|Target/Specificity||This DTX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-48 amino acids from the N-terminal region of human DTX3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DTX3 Antibody (N-term ) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.|
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Provided below are standard protocols that you may find useful for product applications.
DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).
Chastagner, P., et al. EMBO Rep. 7(11):1147-1153(2006)
Takeyama, K., et al. J. Biol. Chem. 278(24):21930-21937(2003)
Kishi, N., et al. Int. J. Dev. Neurosci. 19(1):21-35(2001)
Matsuno, K., et al. Development 121(8):2633-2644(1995)
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