|Application ||WB, FC, E|
|Other Accession||P83871, P83870, NP_116147.1|
|Calculated MW||12405 Da|
|Antigen Region||81-110 aa|
|Other Names||PHD finger-like domain-containing protein 5A, PHD finger-like domain protein 5A, Splicing factor 3B-associated 14 kDa protein, SF3b14b, PHF5A|
|Target/Specificity||This PHF5A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the C-terminal region of human PHF5A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PHF5A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER- alpha. Also involved in pre-mRNA splicing.|
|Cellular Location||Nucleus. Nucleus speckle|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a subunit of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. The protein encoded by this gene contains a PHD-finger-like domain that is flanked by highly basic N- and C-termini. This protein belongs to the PHD-finger superfamily and may act as a chromatin-associated protein. This gene has several pseudogenes on different chromosomes.
Kuwasako, K., et al. Proteins 71(4):1617-1636(2008)
Will, C.L., et al. RNA 10(6):929-941(2004)
Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :
Will, C.L., et al. EMBO J. 21(18):4978-4988(2002)
Zhou, Z., et al. Nature 419(6903):182-185(2002)
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