|Application ||WB, IF, IHC-P, E|
|Calculated MW||52071 Da|
|Antigen Region||177-206 aa|
|Other Names||Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, Vitamin K-dependent protein C light chain, Vitamin K-dependent protein C heavy chain, Activation peptide, PROC|
|Target/Specificity||This PROC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-206 amino acids from the Central region of human PROC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PROC Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).|
|Cellular Location||Secreted. Golgi apparatus. Endoplasmic reticulum|
|Tissue Location||Plasma; synthesized in the liver.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
Tang, W., et al. Blood (2010) In press :
Agapkina, Iu.V., et al. Mol. Biol. (Mosk.) 44(4):613-619(2010)
Witt, I., et al. Blood Coagul. Fibrinolysis 5(4):651-653(1994)
Zhang, L., et al. Blood 80(4):942-952(1992)
Grundy, C.B., et al. Hum. Genet. 89(6):683-684(1992)
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