|Application ||WB, E|
|Other Accession||Q5U2U2, P47941, NP_005198.1|
|Calculated MW||33777 Da|
|Antigen Region||50-79 aa|
|Other Names||Crk-like protein, CRKL|
|Target/Specificity||This CRKL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-79 amino acids from the N-terminal region of human CRKL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CRKL Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May mediate the transduction of intracellular signals.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kim, Y.H., et al. Oncogene 29(10):1421-1430(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Segovis, C.M., et al. J. Immunol. 182(11):6933-6942(2009)
Seo, J.H., et al. Mol. Cell. Biol. 29(11):3076-3087(2009)
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