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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   AIFM2 Antibody (C-term)   

AIFM2 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - AIFM2 Antibody (C-term) AP1355b
    Western blot analysis of AIFM2 Antibody (C-term) (Cat. #AP1355b) in mouse liver tissue lysates (35ug/lane). AIFM2 (arrow) was detected using the purified Pab.
  • IHC-P - AIFM2 Antibody (C-term) AP1355b
    Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with AIFM2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - AIFM2 Antibody (C-term) AP1355b
    AIFM2 Antibody (C-term) (Cat. #AP1355b) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BRQ8
Other Accession Q8BUE4, A5PJM4
Reactivity Human
Predicted Bovine, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 40527 Da
Antigen Region 319-348 aa
Additional Information
Gene ID 84883
Other Names Apoptosis-inducing factor 2, 1---, Apoptosis-inducing factor homologous mitochondrion-associated inducer of death, Apoptosis-inducing factor-like mitochondrion-associated inducer of death, p53-responsive gene 3 protein, AIFM2, AMID, PRG3 {ECO:0000303|PubMed:12135761}
Target/Specificity This AIFM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 319-348 amino acids from the C-terminal region of human AIFM2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAIFM2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AIFM2
Synonyms AMID, PRG3 {ECO:0000303|PubMed:12135761}
Function Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest.
Cellular Location Cytoplasm. Mitochondrion outer membrane.
Tissue Location Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas Both transcripts expressed following p53/TP53 induction. The shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells.
Research Areas
Citations (0)

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AIFM2 is significant homology to NADH oxidoreductases and the apoptosis-inducing factor PDCD8/AIF. The protein has been shown to induce apoptosis. This protein is found to be induced by tumor suppressor protein p53 in colon caner cells.


Ohiro Y., Garkavtsev I.FEBS Lett. 524:163-171(2002)
Wu M., Xu L.-G., Su T.Oncogene 23:6815-6819(2004)

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$ 295.00
$ 99.00
Cat# AP1355b
(40 western blots)
Availability: In Stock
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