|Application ||WB, E|
|Other Accession||NP_001171556.1, NP_001171557.1, NP_003401.2, NP_001171555.1|
|Calculated MW||90522 Da|
|Antigen Region||288-317 aa|
|Other Names||Zinc finger X-chromosomal protein, ZFX|
|Target/Specificity||This ZFX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-317 amino acids from the Central region of human ZFX.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZFX Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable transcriptional activator.|
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Provided below are standard protocols that you may find useful for product applications.
This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined.
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Poloumienko, A. Genome 47(1):74-83(2004)
Agate, R.J., et al. Mol. Biol. Evol. 21(2):384-396(2004)
Murphy, W.J., et al. Nature 409(6820):614-618(2001)
Taylor, D.M., et al. Mol. Reprod. Dev. 48(4):442-448(1997)
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