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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   REC8 Antibody (Center)   

REC8 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - REC8 Antibody (Center) AP13570c
    Anti-REC8 Antibody (Center) at 1:1000 dilution + human testis lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 63 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - REC8 Antibody (Center) AP13570c
    REC8 Antibody (Center) (Cat. #AP13570c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the REC8 antibody detected the REC8 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95072
Other Accession NP_005123.2, NP_001041670.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 62614 Da
Antigen Region 194-222 aa
Additional Information
Gene ID 9985
Other Names Meiotic recombination protein REC8 homolog, Cohesin Rec8p, REC8, REC8L1
Target/Specificity This REC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 194-222 amino acids from the Central region of human REC8.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsREC8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name REC8
Synonyms REC8L1
Function Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity).
Cellular Location Nucleus. Chromosome. Note=In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II (By similarity) Localised to centromeres and spindle poles in endopolyploid tumor cells.
Tissue Location Expressed in testis and thymus. Expressed in the B-cell lines WI-L2-NS and Namalwa (at protein level)
Research Areas
Citations (0)

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This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.


Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)
Erenpreisa, J., et al. Exp. Cell Res. 315(15):2593-2603(2009)
Griffin, J., et al. Syst Biol Reprod Med 54(3):163-165(2008)
Xu, H., et al. Dev. Cell 8(6):949-961(2005)
Prieto, I., et al. Chromosome Res. 12(3):197-213(2004)

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$ 295.00
$ 99.00
Cat# AP13570c
(40 western blots)
Availability: In Stock
Bulk Size
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