|Application ||WB, IHC-P, E|
|Other Accession||Q9QZC2, NP_005752.1|
|Calculated MW||175742 Da|
|Antigen Region||1025-1054 aa|
|Other Names||Plexin-C1, Virus-encoded semaphorin protein receptor, CD232, PLXNC1, VESPR|
|Target/Specificity||This PLXNC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1025-1054 amino acids from the C-terminal region of human PLXNC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PLXNC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Detected in heart, brain, lung, spleen and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
PLXNC1 is a receptor for vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of viral semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity).
Liu, H., et al. Cell 142(5):749-761(2010)
Lazova, R., et al. Am J Dermatopathol 31(2):177-181(2009)
Scott, G.A., et al. J. Invest. Dermatol. 129(4):954-963(2009)
Scott, G.A., et al. J. Invest. Dermatol. 128(1):151-161(2008)
Li, Y., et al. PLoS ONE 3 (7), E2707 (2008) :
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