|Application ||WB, IHC-P, E|
|Other Accession||NP_003571.2, NP_001138244.1|
|Calculated MW||104372 Da|
|Antigen Region||28-57 aa|
|Other Names||Protein FAN, Factor associated with neutral sphingomyelinase activation, Factor associated with N-SMase activation, NSMAF, FAN|
|Target/Specificity||This NSMAF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-57 amino acids from the N-terminal region of human NSMAF.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NSMAF Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N- smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.
Bailey, S.D., et al. Diabetes Care (2010) In press :
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Clarke, C.J., et al. Mol. Pharmacol. 74(4):1022-1032(2008)
Kolzer, M., et al. Biol. Chem. 385(12):1193-1195(2004)
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