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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   NSMAF Antibody (N-term)   

NSMAF Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - NSMAF Antibody (N-term) AP13585a
    NSMAF Antibody (N-term) (Cat. #AP13585a) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the NSMAF antibody detected the NSMAF protein (arrow).
  • IHC-P - NSMAF Antibody (N-term) AP13585a
    NSMAF Antibody (N-term) (Cat. #AP13585a)immunohistochemistry analysis in formalin fixed and paraffin embedded human thyroid tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NSMAF Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92636
Other Accession NP_003571.2, NP_001138244.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 104372 Da
Antigen Region 28-57 aa
Additional Information
Gene ID 8439
Other Names Protein FAN, Factor associated with neutral sphingomyelinase activation, Factor associated with N-SMase activation, NSMAF, FAN
Target/Specificity This NSMAF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-57 amino acids from the N-terminal region of human NSMAF.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNSMAF Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FAN
Function Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N- smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.


Bailey, S.D., et al. Diabetes Care (2010) In press :
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Clarke, C.J., et al. Mol. Pharmacol. 74(4):1022-1032(2008)
Kolzer, M., et al. Biol. Chem. 385(12):1193-1195(2004)

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$ 295.00
$ 99.00
Cat# AP13585a
(40 western blots)
Availability: In Stock
Bulk Size
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