|Application ||WB, E|
|Calculated MW||52285 Da|
|Antigen Region||83-111 aa|
|Other Names||Protein naked cuticle homolog 1, Naked-1, hNkd, hNkd1, NKD1, NKD|
|Target/Specificity||This NKD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-111 amino acids from the N-terminal region of human NKD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NKD1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.|
|Cellular Location||Cell membrane. Cytoplasm|
|Tissue Location||Expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.
Guo, J., et al. PLoS ONE 4 (11), E7982 (2009) : Creyghton, M.P., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5397-5402(2006) Creyghton, M.P., et al. Genes Dev. 19(3):376-386(2005) Yan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 98(26):14973-14978(2001) Katoh, M. Int. J. Oncol. 19(5):963-969(2001)
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