|Application ||WB, E|
|Calculated MW||52285 Da|
|Antigen Region||83-111 aa|
|Other Names||Protein naked cuticle homolog 1, Naked-1, hNkd, hNkd1, NKD1, NKD|
|Target/Specificity||This NKD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-111 amino acids from the N-terminal region of human NKD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NKD1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.|
|Cellular Location||Cell membrane. Cytoplasm|
|Tissue Location||Expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine and spleen.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.
Guo, J., et al. PLoS ONE 4 (11), E7982 (2009) : Creyghton, M.P., et al. Proc. Natl. Acad. Sci. U.S.A. 103(14):5397-5402(2006) Creyghton, M.P., et al. Genes Dev. 19(3):376-386(2005) Yan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 98(26):14973-14978(2001) Katoh, M. Int. J. Oncol. 19(5):963-969(2001)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.