|Application ||WB, E|
|Other Accession||Q5U5A6, Q91ZA8, NP_001004354.1|
|Calculated MW||12492 Da|
|Antigen Region||56-83 aa|
|Other Names||Notch-regulated ankyrin repeat-containing protein, NRARP|
|Target/Specificity||This NRARP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-83 amino acids from the Central region of human NRARP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NRARP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
NRARP may play a role in the formation of somites (By similarity).
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
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