|Application ||WB, E|
|Other Accession||Q9JMF7, NP_001129389.1, NP_065171.2|
|Calculated MW||27031 Da|
|Antigen Region||207-236 aa|
|Other Names||Dolichyldiphosphatase 1, Dolichyl pyrophosphate phosphatase 1, DOLPP1, LSFR2|
|Target/Specificity||This DOLPP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 207-236 amino acids from the C-terminal region of human DOLPP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DOLPP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
DOLPP1 is required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity).
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
Rush, J.S., et al. J. Biol. Chem. 277(47):45226-45234(2002)
Gilley, J., et al. Hum. Mol. Genet. 8(7):1313-1320(1999)
Wedgwood, J.F., et al. J. Biol. Chem. 255(3):1120-1123(1980)
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