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AMIGO1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q86WK6 |
| Other Accession | Q80ZD7, Q80ZD8, NP_065754.2 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55239 Da |
| Antigen Region | 386-415 aa |
| Gene ID | 57463 |
|---|---|
| Other Names | Amphoterin-induced protein 1, AMIGO-1, Alivin-2, AMIGO1 (HGNC:20824) |
| Target/Specificity | This AMIGO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 386-415 amino acids from the C-terminal region of human AMIGO1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | AMIGO1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AMIGO1 (HGNC:20824) |
|---|---|
| Function | Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q80ZD8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q80ZD8} Perikaryon {ECO:0000250|UniProtKB:Q80ZD8}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q80ZD8}. Cell projection, axon {ECO:0000250|UniProtKB:Q80ZD7}. Note=Colocalizes with KCNB1 at high- density somatodendritic clusters on the surface of hippocampal and cortical neurons. Associated with axons of neuronal cells {ECO:0000250|UniProtKB:Q80ZD7, ECO:0000250|UniProtKB:Q80ZD8} |
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Provided below are standard protocols that you may find useful for product applications.
Background
AMIGO1 promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (By similarity).
References
Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Kuja-Panula, J., et al. J. Cell Biol. 160(6):963-973(2003)
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