|Application ||WB, E|
|Calculated MW||54249 Da|
|Antigen Region||143-172 aa|
|Other Names||Hyaluronidase-4, Hyal-4, Chondroitin sulfate endo-beta-N-acetylgalactosaminidase, Chondroitin sulfate hydrolase, CSHY, Hyaluronoglucosaminidase-4, HYAL4|
|Target/Specificity||This HYAL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-172 amino acids from the Central region of human HYAL4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HYAL4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Detected in placenta and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. [provided by RefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Kaneiwa, T., et al. Glycobiology 20(3):300-309(2010)
Fiszer-Szafarz, B., et al. J. Biochem. Biophys. Methods 45(2):103-116(2000)
Csoka, A.B., et al. Genomics 60(3):356-361(1999)
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