|Application ||WB, IHC-P, E|
|Calculated MW||26488 Da|
|Antigen Region||80-108 aa|
|Other Names||Trypsin-2, Anionic trypsinogen, Serine protease 2, Trypsin II, PRSS2, TRY2, TRYP2|
|Target/Specificity||This PRSS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-108 amino acids from the Central region of human PRSS2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRSS2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||In the ileum, may be involved in defensin processing, including DEFA5.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Expressed in Paneth cells, at the base of small intestinal crypts.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7.
Felderbauer, P., et al. Exp. Clin. Endocrinol. Diabetes (2010) In press :
Gao, J., et al. Oncol. Rep. 23(6):1683-1692(2010)
Cevik, Y., et al. Ulus Travma Acil Cerrahi Derg 16(2):125-129(2010)
Andersen, A.M., et al. Pancreas 39(1):26-30(2010)
Johansen, D., et al. Pancreatology 10 (2-3), 229-237 (2010) :
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