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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TLR9 Antibody (C-term)   

TLR9 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TLR9 Antibody (C-term) AP13721B
    TLR9 Antibody (C-term) (Cat. #AP13721b) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the TLR9 antibody detected the TLR9 protein (arrow).
  • FC - TLR9 Antibody (C-term) AP13721B
    TLR9 Antibody (C-term) (Cat. #AP13721b) flow cytometric analysis of Ramos cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NR96
Other Accession NP_059138.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 115860 Da
Antigen Region 842-870 aa
Additional Information
Gene ID 54106
Other Names Toll-like receptor 9, CD289, TLR9
Target/Specificity This TLR9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 842-870 amino acids from the C-terminal region of human TLR9.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTLR9 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TLR9
Function Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.
Cellular Location Endoplasmic reticulum membrane; Single-pass type I membrane protein Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
Tissue Location Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre- dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.


Engin, A., et al. Microbes Infect. 12 (12-13), 1071-1078 (2010) :
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Veltkamp, M., et al. Clin. Exp. Immunol. 162(1):68-74(2010)
Fiola, S., et al. J. Immunol. 185(6):3620-3631(2010)
Selvaraj, P., et al. Tuberculosis (Edinb) 90(5):306-310(2010)

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$ 295.00
$ 99.00
Cat# AP13721B
(40 western blots)
Availability: In Stock
Bulk Size
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