|Application ||WB, IHC-P, E|
|Calculated MW||54590 Da|
|Antigen Region||399-428 aa|
|Other Names||Stromelysin-3, SL-3, ST3, 3424-, Matrix metalloproteinase-11, MMP-11, MMP11, STMY3|
|Target/Specificity||This MMP11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 399-428 amino acids from the C-terminal region of human MMP11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MMP11 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play an important role in the progression of epithelial malignancies.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Specifically expressed in stromal cells of breast carcinomas|
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Provided below are standard protocols that you may find useful for product applications.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Nalpas, B., et al. Gut 59(8):1120-1126(2010)
Ban, J.Y., et al. Life Sci. 86 (19-20), 756-759 (2010) :
Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :
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