|Application ||WB, E|
|Calculated MW||22487 Da|
|Antigen Region||138-167 aa|
|Other Names||Histone H1x, H1FX|
|Target/Specificity||This H1FX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-167 amino acids from the C-terminal region of human H1FX.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||H1FX Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.|
|Cellular Location||Nucleus. Chromosome.|
|Tissue Location||Expressed ubiquitously.|
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Provided below are standard protocols that you may find useful for product applications.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H1 family.
Warneboldt, J., et al. BMC Cancer 8, 388 (2008) :
Stoldt, S., et al. Biol. Cell 99(10):541-552(2007)
Takata, H., et al. FEBS Lett. 581(20):3783-3788(2007)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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