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TNFRSF11B Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP13738c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP13738c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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- Citiations : 0
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TNFRSF11B Antibody (Center) - Product info | |
| Application | WB, IF, IHC
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| Primary Accession | O00300 |
| Other Accession | NP_002537.3 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 46026 Da |
TNFRSF11B Antibody (Center) - Additional info | |
| Gene ID 4982 | |
| Other Names TNFRSF11B; OCIF; OPG; Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin | |
| Target/Specificity This TNFRSF11B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-271 amino acids from the Central region of human TNFRSF11B. | |
| Dilution WB~~1:100~500WB~~1:1000 IF~~1:10~50 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions TNFRSF11B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
TNFRSF11B Antibody (Center) - Protein Information | |
| Name TNFRSF11B | |
| Synonyms OCIF, OPG | |
| Function Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis | |
| Cellular Location Secreted. | |
| Tissue Location Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung | |
TNFRSF11B Antibody (Center) - Related products
AP13738c: TNFRSF11B Antibody (Center)
TNFRSF11B Antibody (Center) - Application data
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TNFRSF11B Antibody (Center) (Cat. #AP13738c) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the TNFRSF11B antibody detected the TNFRSF11B protein (arrow).
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Confocal immunofluorescent analysis of TNFRSF11B Antibody (Center) (Cat#AP13738c) with NCI-H460 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
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TNFRSF11B Antibody (Center) (AP13738c)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TNFRSF11B Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
TNFRSF11B Antibody (Center) - Research Areas
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BACKGROUND
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Liu, J.M., et al. J. Clin. Endocrinol. Metab. 95 (9), E112-E120 (2010) : Lieb, W., et al. Arterioscler. Thromb. Vasc. Biol. 30(9):1849-1854(2010) Paternoster, L., et al. J. Clin. Endocrinol. Metab. 95(8):3940-3948(2010) Hsu, Y.H., et al. PLoS Genet. 6 (6), E1000977 (2010) :
