- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Calculated MW||22988 Da|
|Antigen Region||160-188 aa|
|Other Names||Rho GDP-dissociation inhibitor 2, Rho GDI 2, Ly-GDI, Rho-GDI beta, ARHGDIB, GDIA2, GDID4, RAP1GN1|
|Target/Specificity||This ARHGDIB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-188 amino acids from the C-terminal region of human ARHGDIB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ARHGDIB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GDIA2, GDID4, RAP1GN1|
|Function||Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133).|
|Cellular Location||Cytoplasm, cytosol|
|Tissue Location||Detected in bone marrow, thymus and spleen.|
Provided below are standard protocols that you may find useful for product applications.
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).
Niu, H., et al. Oncol. Rep. 24(2):465-471(2010)
Zhen, H., et al. Int. J. Gynecol. Cancer 20(3):316-322(2010)
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Said, N., et al. Cancer Metastasis Rev. 28 (3-4), 327-333 (2009) :
Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)
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