|Application ||WB, IHC-P, E|
|Calculated MW||29574 Da|
|Antigen Region||101-130 aa|
|Other Names||Nicotinamide N-methyltransferase, NNMT|
|Target/Specificity||This NNMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-130 amino acids from the Central region of human NNMT.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NNMT Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.|
|Tissue Location||Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas|
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Provided below are standard protocols that you may find useful for product applications.
N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq].
Giusti, B., et al. Thromb. Haemost. 104(2):231-242(2010)
Zhang, J., et al. J Zhejiang Univ Sci B 11(2):136-143(2010)
Emanuelli, M., et al. Histol. Histopathol. 25(1):15-20(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
van Driel, L.M., et al. J. Nutr. 139(12):2315-2321(2009)
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