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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   RANGAP1 Antibody (N-term)   

RANGAP1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - RANGAP1 Antibody (N-term) AP13776a
    RANGAP1 Antibody (N-term) (Cat. #AP13776a) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the RANGAP1 antibody detected the RANGAP1 protein (arrow).
  • WB - RANGAP1 Antibody (N-term) AP13776a
    Western blot analysis of RANGAP1 (arrow) using rabbit polyclonal RANGAP1 Antibody (N-term) (Cat. #AP13776a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the RANGAP1 gene.
  • IHC-P - RANGAP1 Antibody (N-term) AP13776a
    RANGAP1 Antibody (N-term) (Cat. #AP13776a)immunohistochemistry analysis in formalin fixed and paraffin embedded human colon tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RANGAP1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P46060
Other Accession NP_002874.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 63542 Da
Antigen Region 20-49 aa
Additional Information
Gene ID 5905
Other Names Ran GTPase-activating protein 1, RanGAP1, RANGAP1, KIAA1835, SD
Target/Specificity This RANGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human RANGAP1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRANGAP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA1835, SD
Function GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.
Cellular Location Cytoplasm. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Note=Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase Mitotic location also requires sumoylation
Tissue Location Highly expressed in brain, thymus and testis.
Research Areas
Citations (0)

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RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.


Zhang, J., et al. Biochem. Biophys. Res. Commun. 375(2):252-255(2008)
Zuccolo, M., et al. EMBO J. 26(7):1853-1864(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Vertegaal, A.C., et al. Mol. Cell Proteomics 5(12):2298-2310(2006)
Vertegaal, A.C., et al. Mol. Cell Proteomics 5(12):2298-2310(2006)

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$ 295.00
$ 99.00
Cat# AP13776a
(40 western blots)
Availability: In Stock
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