|Application ||WB, IHC-P, E|
|Calculated MW||11471 Da|
|Antigen Region||2-31 aa|
|Other Names||Protein S100-A7, Psoriasin, S100 calcium-binding protein A7, S100A7, PSOR1, S100A7C|
|Target/Specificity||This S100A7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-31 amino acids from the N-terminal region of human S100A7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||S100A7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cytoplasm. Secreted. Note=Secreted by a non- classical secretory pathway|
|Tissue Location||Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known.
West, N.R., et al. Oncogene 29(14):2083-2092(2010)
Tieu, D.D., et al. J. Allergy Clin. Immunol. 125(3):667-675(2010)
Tripathi, S.C., et al. PLoS ONE 5 (8), E11939 (2010) :
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
West, N.R., et al. Protein Sci. 18(12):2615-2623(2009)
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