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S100A7 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | P31151 |
| Other Accession | NP_002954.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 11471 Da |
| Antigen Region | 2-31 aa |
| Gene ID | 6278 |
|---|---|
| Other Names | Protein S100-A7, Psoriasin, S100 calcium-binding protein A7, S100A7, PSOR1, S100A7C |
| Target/Specificity | This S100A7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-31 amino acids from the N-terminal region of human S100A7. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | S100A7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | S100A7 |
|---|---|
| Synonyms | PSOR1, S100A7C |
| Cellular Location | Cytoplasm. Secreted. Note=Secreted by a non-classical secretory pathway |
| Tissue Location | Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known.
References
West, N.R., et al. Oncogene 29(14):2083-2092(2010)
Tieu, D.D., et al. J. Allergy Clin. Immunol. 125(3):667-675(2010)
Tripathi, S.C., et al. PLoS ONE 5 (8), E11939 (2010) :
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
West, N.R., et al. Protein Sci. 18(12):2615-2623(2009)
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