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SNX14 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y5W7 |
| Other Accession | Q8BHY8, NP_065201.1, NP_722523.1 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 110182 Da |
| Antigen Region | 580-608 aa |
| Gene ID | 57231 |
|---|---|
| Other Names | Sorting nexin-14, SNX14 |
| Target/Specificity | This SNX14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 580-608 amino acids from the Central region of human SNX14. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SNX14 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SNX14 |
|---|---|
| Function | Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (Probable). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes (PubMed:25848753). Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:25848753, PubMed:25148684). |
| Cellular Location | Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8BHY8} |
| Tissue Location | Widely expressed both in fetal and adult tissues. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein also contains a regulator of G protein signaling (RGS) domain. Regulator of G protein signaling family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. Two transcript variants encoding distinct isoforms have been identified for this gene.
References
Worby, C.A., et al. Nat. Rev. Mol. Cell Biol. 3(12):919-931(2002)
Xu, Y., et al. Biochem. J. 360 (PT 3), 513-530 (2001) :
Teasdale, R.D., et al. Biochem. J. 358 (PT 1), 7-16 (2001) :
Carroll, P., et al. Dev. Dyn. 221(4):431-442(2001)
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