|Application ||WB, IHC-P, E|
|Calculated MW||27091 Da|
|Antigen Region||163-191 aa|
|Other Names||Carcinoembryonic antigen-related cell adhesion molecule 3, Carcinoembryonic antigen CGM1, CD66d, CEACAM3, CD66D, CGM1|
|Target/Specificity||This CEACAM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-191 amino acids from the C-terminal region of human CEACAM3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CEACAM3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Tsavaris, N., et al. J Chemother 21(6):673-680(2009)
Skubitz, K.M., et al. J Transl Med 6, 78 (2008) :
Stern-Ginossar, N., et al. J. Immunol. 179(7):4424-4434(2007)
Ali, C.W., et al. J Gastrointest Cancer 38 (2-4), 108-114 (2007) :
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