|Application ||WB, E|
|Calculated MW||38721 Da|
|Antigen Region||323-351 aa|
|Other Names||Protein Wnt-8b, WNT8B|
|Target/Specificity||This WNT8B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 323-351 amino acids from the C-terminal region of human WNT8B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||WNT8B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expression is restricted to the brain, and more specifically to the forebrain.|
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Provided below are standard protocols that you may find useful for product applications.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy.
Katoh, M., et al. Int. J. Oncol. 30(5):1273-1277(2007)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Deloukas, P., et al. Nature 429(6990):375-381(2004)
Saitoh, T., et al. Int. J. Oncol. 20(5):999-1003(2002)
Saitoh, T., et al. Int. J. Oncol. 20(2):343-348(2002)
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