- CITATIONS: 2
|Application ||WB, E|
|Other Accession||P08419, NP_254275.1|
|Calculated MW||28888 Da|
|Antigen Region||231-260 aa|
|Other Names||Chymotrypsin-like elastase family member 2A, Elastase-2A, CELA2A, ELA2A|
|Target/Specificity||This CELA2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-260 amino acids from the C-terminal region of human CELA2A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CELA2A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts upon elastin.|
|Tissue Location||Pancreas. Not detected in keratinocytes.|
Provided below are standard protocols that you may find useful for product applications.
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Lausen, J., et al. Oncogene 25(9):1349-1357(2006)
Szepessy, E., et al. Pancreatology 6 (1-2), 117-122 (2006) :
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