|Application ||WB, E|
|Other Accession||Q8SPU7, NP_000736.2|
|Calculated MW||53054 Da|
|Antigen Region||187-216 aa|
|Other Names||Neuronal acetylcholine receptor subunit alpha-5, CHRNA5, NACHRA5|
|Target/Specificity||This CHRNA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-216 amino acids from the Central region of human CHRNA5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CHRNA5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).
Wessel, J., et al. Neuropsychopharmacology 35(12):2392-2402(2010)
Erlich, P.M., et al. Hum. Genet. 128(5):491-499(2010)
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Falvella, F.S., et al. J. Natl. Cancer Inst. 102(17):1366-1370(2010)
Li, M.D., et al. PLoS ONE 5 (8), E12183 (2010) :
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